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King Charles argued on Friday that, thanks to early diagnosis, his treatment will be reduced in the New Year.

He urged people to take up cancer screening saying: “Early diagnosis quite simply saves lives.”

bbc.co.uk/news/articles/crl99y…
1/10

Beverley reshared this.

in reply to Kit Yates

So why did the UKNSC advise against rolling out routine prostate screening to all men?

Because benefits and harms must be balanced at population scale—hence a targeted approach.

independent.co.uk/news/health/…

3/10

Beverley reshared this.

in reply to Kit Yates

The draft recommendation: screen every 2 years for men 45–61 with confirmed BRCA1/2 mutations.

Only around 0.3% of men have these, and fewer are in that age band—so targeting maximises benefit, minimises harm.

genomicseducation.hee.nhs.uk/g…
4/10

Beverley reshared this.

in reply to Kit Yates

Part of the answer is economic: modelling for the UKNSC found repeated whole‑population screening was least cost‑effective, while focusing on higher‑risk groups was far more cost‑effective.

nationalscreening.blog.gov.uk/…
5/10

Beverley reshared this.

in reply to Kit Yates

Another part is test accuracy. PSA is not cancer‑specific.

In population screening, even a small drop in specificity means false positives can swamp true positives—causing anxiety and deterring future attendance.

Read more about false positives here
uk.bookshop.org/lists/kit-yate…
6/10

Beverley reshared this.

in reply to Kit Yates

The harms aren’t just false positives.

Overdiagnosis finds cancers so small/slow‑growing they’d never cause problems—yet many people undergo painful or invasive treatments unnecessarily.

doi.org/10.1136/bmj.39470.6432…
7/10

Beverley reshared this.

in reply to Kit Yates

A key problem with the PSA test: it can’t reliably distinguish dangerous cancers from benign conditions like BPH (enlarged prostate), which also raise PSA - which can lead to costly follow‑ups and overtreatment.

nhs.uk/conditions/enlarged-pro…
8/10

Beverley reshared this.

in reply to Kit Yates

Bottom line: UK screening programmes are targeted to those at higher risk to reduce harm and improve value.

With ~9 million in the UK not up to date with at least one screening, if you’ve been invited, don’t miss it.
bbc.co.uk/news/articles/crl99y…
9/10

Beverley reshared this.

in reply to Kit Yates

Adapted from my substack "To Screen or not to Screen?":

open.substack.com/pub/kityates…

10/10

This entry was edited (12 hours ago)

Beverley reshared this.

in reply to Kit Yates

PSA may also lead to painful & invasive investigations - anecdotal experience of a relative followed-up & underwent a number of anxiety-inducing & in some cases painful diagnostic tests but died of something unrelated many years later.
in reply to AnneH

@annehargreaves I'm sorry to hear this. Yes I think overdiagnosis is a real and underappreciated problem.
in reply to Kit Yates

Prostate ailments seem to be tricky to diagnose, while an appreciable number are best left alone, making it more difficult.
in reply to Kit Yates

How NHS can know who has BRCA1/2 mutations without population wide screening for this mutations? Your link suggest that tests for BRCA1/2 mutations are offered to people with already diagnosed cancer.
This entry was edited (1 day ago)



No one has faced trial for 2020 ‘fake electors’ plan. In Wisconsin, it might happen.
https://www.csmonitor.com/USA/Politics/2025/1213/wisconsin-trump-fake-electors-trial?utm_source=flipboard&utm_medium=activitypub

Posted into Now What? @now-what-csmonitor



As inflation weighs on voters, Trump is paying a high price, too
https://www.csmonitor.com/USA/Politics/2025/1213/affordability-trump-prices-inflation?utm_source=flipboard&utm_medium=activitypub

Posted into Now What? @now-what-csmonitor



Bijna 7000 Amerikanen kwamen in 2025 naar NL, vaak op de vlucht voor het groeiende fascisme onder Trump.
Ook waren er 67 asielaanvragen van Amerikanen.
'In Canada, Engeland of Ierland is het bijna onmogelijk om een visum te krijgen. In tegenstelling tot Nederland.
Voor trans en queer mensen is de VS een bijzonder onveilige plek geworden.'
nos.nl/artikel/2594484-nederla…

Egon Willigh☮gen 🟥 reshared this.

in reply to Silly🤸🏾‍♀️Putty

Laat je validistische geleuter graag achterwege. Dit soort opmerkingen maak je mensen stuk mee. Daar is niets positiefs, verbindends of antifa's aan.







NL: aantal OV-checkins per week plus gemiddelde laatste 52 weken.


‘Arriving in my ancestral town offered me closure’: Inside the rise of roots tourism in Italy byteseu.com/1626309/ #citizenship #emigration #Family #Italy #relocation #Sicily


in reply to Aetherius Eldritch ⛤🧙‍♂️🎙️📻

Una pizarra verde con texto blanco escrito a mano. En la parte superior de la pizarra, en letras grandes, está escrito "COMBINACIONES PELIGROSAS". Debajo de eso, hay tres líneas de texto, cada una precedida por un guion. Las líneas de texto son:

  • Ignorancia y poder
  • Soberbia y dinero
  • Tos y diarrea

Proporcionado por @altbot, generado de forma privada y local usando Gemma3:27b

🌱 Energía utilizada: 0.070 Wh



Het verhaal over een vrouw uit het netwerk van mijn man, die zichzelf niet meer was en het leven niet meer aankon. Een goede reminder dat je de overgang serieus moet nemen. mastodon.social/@jackyan/11571…

in reply to This spaceship does not exist

A digital painting depicts a group of people dining in a spacious, brightly lit room with large windows overlooking a futuristic cityscape and a large, saucer-shaped flying object in the sky. The foreground features a person with dark hair styled in a bob, wearing a light green dress and red earrings, looking off to the side with a focused expression. Several other people are seated at tables, engaged in conversation or looking in various directions. The room has a mid-century modern aesthetic with red chairs and white tablecloths. A partially visible person in an orange jacket is visible, along with other individuals of varying ages and appearances. A drink in a martini glass sits on the table in front of the foreground person.

Provided by @altbot, generated privately and locally using Gemma3:27b

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Lurup Impressionen – Hamburg und die Geduld der Fuhrleute

#silentsunday

urbanister.photos/stadtfotogra…

in reply to Dirksen ¯\_( ͡° ͜ʖ ͡°)_/¯



Hello people. Look at your house, now back to me. Now back to your house, now back to me. Sadly your house isn't me. But if you switch to #homeassistant your house could be automated like me.


Just sittin’ here, feelin’ blue.

Ms: London, British Library, Add. 62925, f. 60v (13th c.).
troet.cafe/@dailymedievalcats/…

Algje reshared this.




#mist : visible watery vapor suspended in the atmosphere, at or near the surface of the earth

- German: der Nebel

- Italian: nebbia

- Portuguese: neblina

- Spanish: neblina

------------

Guess the next word of the hour @ 24hippos.com

#mist