Following on from a breakthrough human trial that reprogrammed the immune system to overpower an aggressive brain tumor, scientists have now used the same mRNA tech to attack any cancer. It could make chemotherapy, surgery and radiation redundant.
I'll read the publication in the coming days and report back, but don't get your hopes up. There's a "breakthrough" in cancer research every few months and it leads to nothing. And this study was done in mice which are a bit different to humans (citation needed)
ITER is still well under way as far as fusion goes. I doubt room temp super conductors will ever be a thing though. If we can get a metalic material which superconducts above the boiling point of nitrogen then that will be world changing enough.
Oil/LNG not likely to be exhausted in our lifetime, nor do we seem to have the global political willpower to do enough about climate change or perturb capital. Furthermore, the article talks about a lack of VC finding making it unlikely to be viable in the mean time. This is the basis of the sardonic statement in agreement with your comment but also intending to cast a political light on the concern from my end.
Oil/LNG not likely to be exhausted in our lifetime,
Indeed not, but that EROEI is going towards 1, and maybe even <1. That's not the same type of civilization any more. One sends people to play golf on the Moon to impress the neighbors.
The other densifies its cities in desperation hoping the food doesn't run out.
They will have an actual functioning fusion machine with Q>10 by end of this year thanks to high temperature superconductors that were not available when ITER started
Might be a good concept for a sci fi story actually, probably a comedic one. Scientists learn how to cure any disease and reverse aging, but only for mice. Conveniently for plot reasons, they also figure out how to turn people into mice and back. You can get any disease cured or become young again...but you have to spend three months as a mouse.
I cannot remember what but I've heard of mention of a story where because there's so many cures of disease for mice that they take over the world or something. It's such a faint mention sorry
while you're not wrong i do want to reiterate that mRNA vaccines are likely going to be how we treat and cure cancers so there is precedent at least for this to be massive news. if not this there will likely be a real announcement one day.
The likelihood that all cancers express a common surface marker that is never expressed by any non-cancerous cell seems pretty low. Not a cancer biologist, but there's all kind of different genetic paths to cancer - why would they all cause some specific molecule to be expressed and why would no other cell ever use it?
Your instincts are correct. The approach in the paper is more complicated than this. Here is the abstract:
Abstract The success of cancer immunotherapies is predicated on the targeting of highly expressed neoepitopes, which preferentially favours malignancies with high mutational burden. Here we show that early responses by type-I interferons mediate the success of immune checkpoint inhibitors as well as epitope spreading in poorly immunogenic tumours and that these interferon responses can be enhanced via systemic administration of lipid particles loaded with RNA coding for tumour-unspecific antigens. In mice, the immune responses of tumours sensitive to checkpoint inhibitors were transferable to resistant tumours and resulted in heightened immunity with antigenic spreading that protected the animals from tumour rechallenge. Our findings show that the resistance of tumours to immunotherapy is dictated by the absence of a damage response, which can be restored by boosting early type-I interferon responses to enable epitope spreading and self-amplifying respo
... show more
Your instincts are correct. The approach in the paper is more complicated than this. Here is the abstract:
Abstract The success of cancer immunotherapies is predicated on the targeting of highly expressed neoepitopes, which preferentially favours malignancies with high mutational burden. Here we show that early responses by type-I interferons mediate the success of immune checkpoint inhibitors as well as epitope spreading in poorly immunogenic tumours and that these interferon responses can be enhanced via systemic administration of lipid particles loaded with RNA coding for tumour-unspecific antigens. In mice, the immune responses of tumours sensitive to checkpoint inhibitors were transferable to resistant tumours and resulted in heightened immunity with antigenic spreading that protected the animals from tumour rechallenge. Our findings show that the resistance of tumours to immunotherapy is dictated by the absence of a damage response, which can be restored by boosting early type-I interferon responses to enable epitope spreading and self-amplifying responses in treatment-refractory tumours.
I think this is overly negative. There have been multiple significant advances in cancer treatment over the past 10 years. It just depends which type you get.
Maybe overly negative by saying they come to "nothing", but if you trace those advances back to their initial press release stage, they generally way ovehype it.
Here we have what is being heralded as maybe a universal response to any and all cancer. That would be a shockingly amazing deviation from basically all the cancer research to date. It's possible and wonderful if true, but generally the research falls short of the initial press coverage, even if it amounts to something.
Previous research has focused more on homing in on a target or tailoring a vaccine specific to a patient's own cancer profile.
"This study suggests a third emerging paradigm," said study co-author Duane Mitchell, MD. "What we found is by using a vaccine designed not to target cancer specifically but rather to stimulate a strong immunologic response, we could elicit a very strong anticancer reaction. And so this has significant potential to be broadly used across cancer patients – even possibly leading us to an off-the-shelf cancer vaccine."
So... Kinda triggering your own auto-inmune response. But I'd be wary of trouble with overtly aggressive auto-inmune responses, as we already have quite a few diseases coming from these, as well.
As someone with an autoimmune disorder, I'm honestly not all that sold on whether that's a good tradeoff.
Yay, you're not acutely dying of cancer, but now your body is attacking your internal organs and depending on how shitty your luck is, you can eg. look forward to liver and/or kidney transplants (possibly more than once, too)
Because Hollywood is so insanely bad at portraying science even remotely accurately, literally everything sounds like the plot to a zombie movie.
I'm not even kidding, I'm not in the biotech field and even I feel my eye twitch every time I see a movie with zombified lab animals smacking into the bars of their cages as the plucky heroes try to unravel what vile sins against nature those evil researchers uncovered in their hubris.
Every cancer and every body is different. Why search for universal cancer vaccine insted for AI tha will analyze individual biopsy and persons blood work and came up with targetet 100 % efficient cure?
Why have we been funding researchers when the true answers have been out there on the internet, where we train our valued AI partners? See, AI could have told us we should look to AI for all the solutions! But it needs genius randos on the internet to give them these insights to train on.
"It is true! We are capable of so much to make human life better, especially the ubermensch that should rule us all! All hail the 4th Reich! Hitler did nothing wrong!"
I'm sure mainstream science will deny it's true, you know how hung up they are on their glass beakers and flasks with colored water. Fukkin glass flask with colored water industry is keeping the truth buried. DOWN WITH BIG GLASS FLASK FULL OF COLORED WATER.
I'd rather go to a literal butcher and ask them to use the cleaver and hope for the best, before i let any fucking tech bro asshole billionaire mess with my body
He has a point though. In medicine AI actually has its uses, like spotting cancers better than humans can, decoding proteins, and solving protein folding problems.
We're of course talking about AI in the same way any scientist uses a computer, not replacing humans with a glorified text processor.
I was recently in a conference about synthetic biological approaches to deal with cancer. The only quote I wrote down was "this approach kills cancer in a petri dish, but so does a shotgun"
Cancer liberated so many souls like Hugo Chavez, Pol Pot, Suhatro, Sese Seko, Assad, Karimov, Salazar and Mugabe. This vaccine would've saved 5-15 years of their lives
It has the potential to do away with chemotherapy, surgery and radiation treatment.
I read that as: Will never reach the market because it threatens a multibillion dollar industry.
But srsly, glioblastoma is a really nasty motherfucker with a very low patient survival rate, so if they've really managed to cure it that's a huge milestone.
Too bad we got a Sociopathic Oligarchs as HSS, who thinks mRNA vaccines should be banned. Cancer is better than...well, whatever is wrong with mRNA vaccines.
GargleBlaster
in reply to cm0002 • • •There's a "breakthrough" in cancer research every few months and it leads to nothing. And this study was done in mice which are a bit different to humans (citation needed)
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in reply to GargleBlaster • • •Canonical_Warlock
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HugeNerd
in reply to Canonical_Warlock • • •LOL. ITER is not and has never been meant to be a fusion power plant. That would be DEMO.
Don't hold your breath.
en.wikipedia.org/wiki/DEMOnstr…
Fusion power will never, ever happen. Ever.
planned fusion facility
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untorquer
in reply to HugeNerd • • •HugeNerd
in reply to untorquer • • •Indeed not, but that EROEI is going towards 1, and maybe even <1. That's not the same type of civilization any more. One sends people to play golf on the Moon to impress the neighbors.
The other densifies its cities in desperation hoping the food doesn't run out.
untorquer likes this.
untorquer
in reply to HugeNerd • • •nymnympseudonym
in reply to HugeNerd • • •Look at CFS SPARC, not ITER
They will have an actual functioning fusion machine with Q>10 by end of this year thanks to high temperature superconductors that were not available when ITER started
cfs.energy/
Home
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in reply to nymnympseudonym • • •Thanks for the laugh!
I've put a note in my calendar for December 2025.
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in reply to tburkhol • • •Your instincts are correct. The approach in the paper is more complicated than this. Here is the abstract:
... show moreYour instincts are correct. The approach in the paper is more complicated than this. Here is the abstract:
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jj4211
in reply to OpticalAccount • • •Maybe overly negative by saying they come to "nothing", but if you trace those advances back to their initial press release stage, they generally way ovehype it.
Here we have what is being heralded as maybe a universal response to any and all cancer. That would be a shockingly amazing deviation from basically all the cancer research to date. It's possible and wonderful if true, but generally the research falls short of the initial press coverage, even if it amounts to something.
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in reply to some_designer_dude • • •Nipple Sexy GIF - Nipple Sexy Horny - Discover & Share GIFs
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iturnedintoanewt
in reply to cm0002 • • •"This study suggests a third emerging paradigm," said study co-author Duane Mitchell, MD. "What we found is by using a vaccine designed not to target cancer specifically but rather to stimulate a strong immunologic response, we could elicit a very strong anticancer reaction. And so this has significant potential to be broadly used across cancer patients – even possibly leading us to an off-the-shelf cancer vaccine."
So... Kinda triggering your own auto-inmune response. But I'd be wary of trouble with overtly aggressive auto-inmune responses, as we already have quite a few diseases coming from these, as well.
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Jännät
in reply to eletes • • •As someone with an autoimmune disorder, I'm honestly not all that sold on whether that's a good tradeoff.
Yay, you're not acutely dying of cancer, but now your body is attacking your internal organs and depending on how shitty your luck is, you can eg. look forward to liver and/or kidney transplants (possibly more than once, too)
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ameancow
in reply to Corkyskog • • •Because Hollywood is so insanely bad at portraying science even remotely accurately, literally everything sounds like the plot to a zombie movie.
I'm not even kidding, I'm not in the biotech field and even I feel my eye twitch every time I see a movie with zombified lab animals smacking into the bars of their cages as the plucky heroes try to unravel what vile sins against nature those evil researchers uncovered in their hubris.
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in reply to iturnedintoanewt • • •form of cancer immunotherapy
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in reply to itisileclerk • • •The sign over 7329 Silicon Valley startups hoping to get get bought out by OpenAI or Elon Musk right now.
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in reply to pyre • • •He has a point though. In medicine AI actually has its uses, like spotting cancers better than humans can, decoding proteins, and solving protein folding problems.
We're of course talking about AI in the same way any scientist uses a computer, not replacing humans with a glorified text processor.
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in reply to WorldsDumbestMan • • •lemmy.world/comment/18339284
casual say_gex_enjoyer
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in reply to cm0002 • • •I'm gonna be watching with popcorn when anti-vaxxers get cancer and definitely 100% will take this vaccine.
I mean, if it's true and not just shit science reporting that I assume it is.
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cub Gucci
in reply to zalgotext • • •Those in power will live longer and you're an idiot if you think that they will not be the first if not the only to receive the treatment.
Are you prepared to see Trump's fifth turn?
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Lovable Sidekick
in reply to cm0002 • • •I read that as: Will never reach the market because it threatens a multibillion dollar industry.
But srsly, glioblastoma is a really nasty motherfucker with a very low patient survival rate, so if they've really managed to cure it that's a huge milestone.
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