Can THC Turn Back The Clock? Cannabis Reverses Brain Aging, Boosts Mental Capacity, New Study Suggests
Initially, THC boosted brain metabolism and synaptic protein levels, indicative of heightened cognitive processes. Subsequently, it shifted towards reducing metabolic activities in the body akin to the effects seen with caloric restriction or intensive exercise, known for their anti-aging benefits.
Benzinga
THC brain aging reversal: New study reveals how low-dose THC can enhance cognitive function and reverse aging in the elderly. Read now!Patricio Liddle (Benzinga)
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Illegalmexicant
in reply to karashta • • •metallic_substance
in reply to Illegalmexicant • • •The Pantser
in reply to karashta • • •ohYouKnow
in reply to The Pantser • • •Is this why you posted the same comment twice?
Once here
And the other here
The Pantser
2024-08-24 02:24:12
The Pantser
in reply to ohYouKnow • • •yokonzo
in reply to The Pantser • • •ohYouKnow
in reply to The Pantser • • •Sanctus
in reply to ohYouKnow • • •intensely_human
in reply to The Pantser • • •CaptainSpaceman
in reply to The Pantser • • •Angry_Autist (he/him)
in reply to The Pantser • • •I started getting high later in life (25) and had shit memory beforehand.
It's a bit less shit now, take that as you will.
crawancon
in reply to karashta • • •ivanafterall ☑️
in reply to karashta • • •Angry_Autist (he/him)
in reply to ivanafterall ☑️ • • •southsamurai
in reply to karashta • • •The publication itself, which seems to be legit, and well done.
Haven't had a chance to read all of it, but it isn't badly executed by a quick scan.
Edit: I've had a chance to read it in full.
About half of it is over my head. Just don't have the biochemical background to be able to interpret much of the metabolites they were measuring.
That being said, that stuff isn't actually important for casual interest.
Here's the key points I found:
First, the study was mice only. While mice are excellent for this kind of work, you can't guarantee things will be a 1:1 result in Holland p.
Second, the study was for low dose levels, and only delta-9 thc, with no other cannabinoids being used at all.
Third, the study was relatively short, with 42 days being the longer end.
Fourth, and this is the cool part, changes in the relevant metabolites and brain samples had benefit at the 14 day mark. So, if this do
... show moreThe publication itself, which seems to be legit, and well done.
Haven't had a chance to read all of it, but it isn't badly executed by a quick scan.
Edit: I've had a chance to read it in full.
About half of it is over my head. Just don't have the biochemical background to be able to interpret much of the metabolites they were measuring.
That being said, that stuff isn't actually important for casual interest.
Here's the key points I found:
First, the study was mice only. While mice are excellent for this kind of work, you can't guarantee things will be a 1:1 result in Holland p.
Second, the study was for low dose levels, and only delta-9 thc, with no other cannabinoids being used at all.
Third, the study was relatively short, with 42 days being the longer end.
Fourth, and this is the cool part, changes in the relevant metabolites and brain samples had benefit at the 14 day mark. So, if this does translate to human effects, short term, low dose use of delta-9 may be a valuable option. That's years away before this could be confirmed as valid for humans, but the effects were significant.
All of that means that just smoking weed, you aren't going to duplicate the conditions of the study. If you're taking in enough to get high, you're at a higher dose than the study, and that may cause an opposite effect long term.
This is a very focused experiment, with well defined limits and goals. The information gained can not be used as an indicator that smoking herb as an adult human will give any benefit, much less what is in the title of the article.
Think of this study as step one in maybe ten steps you get to the point where it would be useful for indicating benefits in humans, assuming everything went right along the way.
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pbbananaman
in reply to southsamurai • • •southsamurai
in reply to pbbananaman • • •It was three different doses, 0.3, 1, and 3 mg/kg per day
It was also delivered via subcutaneous pump, which is usually done with a mind towards a gradual dosing rather than a single push of the total amount all at once.
The kind of pump listed in the article previously linked was an osmotic pump.
Here's an excerpt from a different paper describing the various methods for substance delivery:
Osmotic pumps are internally implanted devices that use an osmotic displacement system to infuse a preloaded substance into an animal. Use of these pumps permits constant dosing without the need to handle an animal after the initial implant surgery. Extracellular fluid is absorbed at a constant rate by an osmotic salt layer immediately beneath the permeable outer membrane. As the osmotic layer absorbs fluid, it swells and puts pressure on an impermeable reservoir in the center of the pump. The reservoir then expels the loaded substance from the pump at
... show moreIt was three different doses, 0.3, 1, and 3 mg/kg per day
It was also delivered via subcutaneous pump, which is usually done with a mind towards a gradual dosing rather than a single push of the total amount all at once.
The kind of pump listed in the article previously linked was an osmotic pump.
Here's an excerpt from a different paper describing the various methods for substance delivery:
Osmotic pumps are internally implanted devices that use an osmotic displacement system to infuse a preloaded substance into an animal. Use of these pumps permits constant dosing without the need to handle an animal after the initial implant surgery. Extracellular fluid is absorbed at a constant rate by an osmotic salt layer immediately beneath the permeable outer membrane. As the osmotic layer absorbs fluid, it swells and puts pressure on an impermeable reservoir in the center of the pump. The reservoir then expels the loaded substance from the pump at a constant rate through a flow moderator. The outflow can pass directly into the tissue surrounding the pump, or a cannula can be attached to the pump to direct the flow into a blood vessel or specific tissue.
Osmotic pumps are cylindrical in shape and come in sizes small enough for mice. These devices are surgically implanted either subcutaneously or intraperitoneally. The flow rate is fixed, and the duration of action varies from 3 d to 6 wk, depending on the size of the pump and the delivery rate selected. Pumps cannot be refilled but can be implanted sequentially to prolong dosing.
I'm not up on the dosing levels in humans, So I I don't have the ability to know offhand if 3mg/kg spread over the day is unusually high (pun partially intended) or not. There's a section I can't find easily (I'm actually dyslexic so it takes me a while to get through this kind of dense and complicated writing) where they mentioned having a higher dose as a point of comparison.
Administration of Substances to Laboratory Animals: Equipment Considerations, Vehicle Selection, and Solute Preparation
PubMed Central (PMC)pbbananaman
in reply to southsamurai • • •Thanks this is a lot of great detail on the dosing mechanism that I think is really interesting. I love reading up on the experimental details and the actually components used to make these experiments work.
300mg of orally ingested THC spread out over 24 hours is about equivalent to consuming 1 typical candy/gummy every hour for 24 hours of the day. A reasonable or average or normal person would be uncomfortably high at these dosages. I also imagine the bioavailability of oral ingestion is less than the dosing mechanism you described although I’m not sure (is that getting taken up through the lymphatic system? How does it differ from oral ingestion or injection into the bloodstream?).
Fascinating stuff, thanks for sharing your knowledge.
southsamurai
in reply to pbbananaman • • •Osmotic pumps tend to be equivalent to a transdermal patch in how the substance spreads through the body, but bypasses the need to go through skin. So, faster initially, but otherwise the dose over time would be the same, assuming the transdermal patch was able to maintain dosage (they aren't, there's a drop-off).
And, just as you said, the entire dose is taken in without any degradation by digestion, or being bound in something.
What I have zero clue about is what difference it would make in terms of numbers. It is equivalent in speed of uptake to subQ or IM injection, which is essentially immediate, just with a slight curve at the very beginning, so tiny it won't be noticeable to someone that experienced all those deliveries.
Vs IV, the initial release is slower with osmotic pumps, but the sustain of the pumps makes everything after that different.
Basically, the pump goes under the skin and leaks the substance into the intracellular fluids, to be taken up by capillaries into the bloodstream.
Yer Ma
in reply to karashta • • •fsxylo
in reply to karashta • • •OsrsNeedsF2P
in reply to fsxylo • • •CeruleanRuin
in reply to OsrsNeedsF2P • • •weariedfae
in reply to karashta • • •Angry_Autist (he/him)
in reply to weariedfae • • •Most days I microdose by diluting extract in glycerine, roughly 1/4 of a joint paced out thru the day.
Works wonders for my EDS, and I don't feel high at all and have a ton more executive control.
Can't really reply on the cognitive decline but I'm pushing 50 and still in the top .5%
Long Covid did drop me a bit tho, but I guess when you start with a straight eight, losing two cylinders isn't so bad.
LustyArgonian
in reply to weariedfae • • •It would be better to microdose lithium if you really don't want to be high imo. 5-20mg range, can be intermittent (doses for bipolar are in the 100mg range and up). There's already lithium in some water supplies and in foods like potatoes, so a small amount in a microdose normally doesn't affect anyone negatively.
ncbi.nlm.nih.gov/pmc/articles/…
ncbi.nlm.nih.gov/pmc/articles/…
ncbi.nlm.nih.gov/pmc/articles/…
I will say over time your body will adjust to cannabis so if you microdose at night consistently before bed, you'll just sleep it off anyway and eventually it won't even get you high anymore.
Beyond its Psychiatric Use: The Benefits of Low-dose Lithium Supplementation
PubMed Central (PMC)southsamurai
in reply to weariedfae • • •workerONE
in reply to karashta • • •remotelove
in reply to workerONE • • •Angry_Autist (he/him)
in reply to remotelove • • •ikidd
in reply to karashta • • •HorseRabbit
in reply to karashta • • •LustyArgonian
in reply to HorseRabbit • • •Reefers 🫧
Eta: lol the downvote is even funnier
Thorny_Insight
in reply to karashta • • •like this
Chozo likes this.
Angry_Autist (he/him)
in reply to Thorny_Insight • • •It can also be true independent of one's liking it.
That little aphorism you just trotted out is a thought terminating cliche, something that contributes nothing and artificially ends discussion.
You chose it deliberately to denigrate the study with zero evidence, and 11 people agreed with you.
Disturbing for lemmy.
we_avoid_temptation
in reply to Angry_Autist (he/him) • • •Angry_Autist (he/him)
in reply to we_avoid_temptation • • •And now there's an explicit block here, free for you.
You don't get to 'it's just a prank bro' someone else's stupidity.
obre
in reply to Angry_Autist (he/him) • • •Angry_Autist (he/him)
in reply to obre • • •obre
in reply to Angry_Autist (he/him) • • •Angry_Autist (he/him)
in reply to obre • • •I think I'd rather trust the opinion of my degreed therapist than some rando on the internet, and even with my neurodivergences, she considers me to be a mentally fit and motivated individual.
There really should be a consequence for amateur psychology copypastas.
obre
in reply to Angry_Autist (he/him) • • •Angry_Autist (he/him)
in reply to obre • • •Again, she's got a degree, you likely don't. I trust her judgment and it hasn't been wrong in years. Please go bother someone else before I excise you from my internet experience forever.
Bitch I have been posting on the internet since before it had pictures, and if you think a thousand posts in a month is significant, then you don't want to hear about when I still had a reddit account.
Yes she knows, no she is not concerned and even considers it good therapy for me to practice handling my EDS, which I have to say has been a significant improvement in my quality of life. I mean just look at this post, I BARELY insulted you! 5 years ago that wouldn't be the case and confronted with your rancid presence I would likely already be banned.
You are concern trolling and on any rational media platform that should be an instaban.
CeruleanRuin
in reply to obre • • •ShepherdPie
in reply to CeruleanRuin • • •Lost_My_Mind
in reply to Thorny_Insight • • •AlecSadler
in reply to karashta • • •tyrant
in reply to AlecSadler • • •TSG_Asmodeus (he, him)
in reply to karashta • • •A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice - Nature Medicine
NatureGrass
in reply to karashta • • •RobotToaster
in reply to Grass • • •LustyArgonian
in reply to karashta • • •Boomkop3
in reply to karashta • • •MonkderVierte
in reply to karashta • • •sinceasdf
in reply to karashta • • •Lmao benzinga the pinnacle of science news
There is a real study it's referencing at least but these fucks are probably just trying to pump weed stocks
Swedneck
in reply to sinceasdf • • •sumguyonline
in reply to karashta • • •Want to improve your brain? Find consistent ways to reduce stress and perform them daily(like an hour walk outside). That will make you feel and think like a younger you.
ShepherdPie
in reply to sumguyonline • • •Dkarma
in reply to ShepherdPie • • •Laborer3652
in reply to karashta • • •Captain Poofter
in reply to Laborer3652 • • •UNY0N
in reply to Captain Poofter • • •Dkarma
in reply to UNY0N • • •Plopp
in reply to Laborer3652 • • •THCDenton
in reply to Laborer3652 • • •ashok36
in reply to Laborer3652 • • •Dkarma
in reply to Laborer3652 • • •Laborer3652
in reply to Dkarma • • •Matriks404
in reply to karashta • • •Well, I don't know if we'll be able to reverse brain aging anytime soon, but we at least know some ways of slowing it down, like by language learning or some other mental tasks.
I personally recommend at least giving a try for learning a new foreign language, it's fascinating journey and even it might be hard at first it's very satisfying in the end. And some people might say that it's not worth it because of AI, but come on, you can still do it for fun, and bigger cultural understanding.
werefreeatlast
in reply to karashta • • •Omgpwnies
in reply to werefreeatlast • • •Kintarian
in reply to karashta • • •Leate_Wonceslace
in reply to Kintarian • • •