Skip to main content




Using a range of computational method, P307 was screened against the pool of proteins produced by the bacterium Acinetobacter baumannii.

This revealed five bacterial peptidoglycan hydrolases, two of which had the potent ability to kill harmful species of Gram-positive and Gram-negative bacteria
both in vitro and in mice.

They retained this ability even after having been exposed to high temperatures,
with further experiments pointing to unique structural properties underlying this stability.

Taken together, these findings highlight an effective method to identify new bacterial-derived peptidoglycan hydrolases that could serve as antimicrobial agents

elifesciences.org/digests/9826…






–10° (13°F for you Imperials) in my little town this morning. Big boy pants it is then

#winter #cold #goodbyeshorts

in reply to James Endres Howell has moved

I remember watching an episode of Bear Grylls in Siberia as a kid.

He said something like, "it's super cold here, the temperature at night could fall as low as –20°C". And I thought, WTF, it's not even that cold :D You should've come in winter!




Trump’s new nominee to head the FBI is being very open about how he’ll persecute MAGA’s enemies. A shrewd observer of autocracy explains how far he’ll be able to get—and why there’s cause for serious worry.

trib.al/fYpKOPe



Why would anyone be celebrating this? Genuinely don’t understand it. Seems silly and hyperpartisan brained.

From: @GottaLaff
mastodon.social/@GottaLaff/113…



@emptywheel on fire today calling out all the people like Ken Dilanian, NBC & Alex Thompson, Politico for failing to cover the Hunter Biden story in context because they were busy being dick pic sniffers. Clip from 3-1-2024 on the @nicolesandler @lolgop @GottaLaff




[$] The rest of the 6.13 merge window

The 6.13 merge window closed with the release of 6.13-rc1 on December 1. By that time, 11,307 non-merge commits had been pulled into the mainline repository; about 9,500 of those [...]

lwn.net/Articles/998990/ #LWN

#LWN


Has global warming accelerated in recent decades? If we look at the rate of warming between 1970 and 2008 and extend it through present, we see that almost all years since 2015 are above the previous trend.




• Why we should give #AI the side-eye

• How the “Low Ambition Coalition” is slow-walking #plastics cleanup

• Why #songbirds are getting divorced

• Where a #dog is barking up the right #tree

Details in “This Week in #Water” from H2O Radio! bit.ly/3CzL6tn




A Beginner’s Guide to Building Outdoor Light Shows Synchronized to Music with Open Source Tools
#Docker #Community #Community #Opensource

docker.com/blog/a-beginners-gu…




You've got until December 5th to grab the JetBrains 30% discount on PyCharm- ALL proceeds go to the PSF! Help #PowerPython and the PSF and grab the deal today 💸 #python

lp.jetbrains.com/psf-q4-2024-f…



A record-breaking December 1 tree. Feels like we all need a bit more sparkle and hope right now.